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there are pieces of the protein that stick down into the cell and they also change so it’s a receptor changes the interior pieces of the protein the receptor also change and one those pieces change they allow it to couple to signaling molecules within the cell now years ago pharmacologist used to talk about a drug that wasn’t agonist to activate the receptor or not activated and I always thought that the receptor was sort of like a switch to turn it on in turn it off and the signals produced now today there’s a

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